顾春艳（邮箱：guchunyan@njucm.edu.cn），博士，教授，博士生导师，南京中医药大学病理学与病理生理学系主任。美国犹他大学williamhill体育在线登录、爱荷华大学williamhill体育在线登录博士后；江苏省“六大人才高峰”创新团队带头人；江苏省优秀青年科学基金获得者；江苏省“333高层次人才培养工程”中青年科学技术带头人；江苏省“双创计划”团队项目核心成员；中华医学会病理学分会病理学教学工作委员会委员、中国病理生理学会中医专委会委员、中国抗癌协会抗癌药物专委会委员、中华中医药学会中药毒理与安全性研究分会委员、中国老年学和老年医学学会老年病学会血液学专家委员会常务委员、江苏省病理生理学会常务理事、民盟江苏省委青委会副主任委员等；Signal transduction and targeted therapy、Molecular Cancer、Acta Pharmaceutica Sinica B、Advanced Science、British Journal of Pharmacology等学术杂志审稿人。
主要从事恶性肿瘤的发病机制与药物靶点发现研究，主持国家自然科学基金项目5项、江苏省“六大人才高峰”创新团队项目1项、江苏省自然科学基金项目2项、山东省自然科学基金创新发展联合基金1项、江苏省方剂高技术研究重点实验室重点项目1项，参与江苏省“双创计划”团队项目1项；发表SCI论文逾50篇，累计影响因子逾500；获得国家发明专利授权8项；获得2023年江苏省高等学校科学技术研究成果一等奖及2024年南京中医药科学技术奖一等奖；获得江苏省研究生教育改革成果优秀奖；负责国家研究生教育智慧教育平台首批上线的研究生课程《高等病理学》；主持江苏省研究生教育教学改革课题1项，南京中医药大学中西医临床医学品牌专业教学改革研究开放课题重点课题1项，南京中医药大学本科课程思政精品课程1门。指导江苏省优秀博士学位论文1人次、江苏省优秀毕业生2人次、国家奖学金4人次；国家级大学生创新创业训练计划3项、江苏省“挑战杯”大学生创业计划竞赛银奖2项、“互联网+”江苏省大学生创新创业大赛二等奖2项、“全国大学生基础医学创新研究暨实验设计论坛”本科院校基础临床赛道省级三等奖3项、中医药赛道省级一等奖1项且获全国总决赛国家银奖。
近五年代表性研究论文：
(1)Ling Wang, Jie Min, Jinjun Qian, Xiaofang Huang, Xichao Yu, Yuhao Cao, Shanliang Sun, Mengying Ke, Xinyu Lv, Wenfeng Su, Mengjie Guo, Nianguang Li, Shiqian Qi#, Hongming Huang#, Chunyan Gu#, Ye Yang#. SAE1 promotes tumor cell malignancy via SUMOylation and liquid–liquid phase separation facilitated nuclear export of p27, Acta Pharmaceutica Sinica B, 2025, ISSN 2211-3835. （医学一区，IF：14.7）
(2)Yuhao Cao, Tianyi Yu, Ziang Zhu, Yuanjiao Zhang, Shanliang Sun#, Nianguang Li#, Chunyan Gu#, Ye Yang#. Exploring the landscape of post-translational modification in drug discovery. Pharmacology & Therapeutics, 2025, 265:108749. （医学一区，IF: 11.99）
(3)Zhendong Deng, Shanliang Sun, Nian Zhou, Yumeng Peng, Long Cheng, Xichao Yu, Yuxia Yuan, Mengjie Guo, Min Xu, Yuexin Cheng, Fan Zhou#, Nianguang Li#, Ye Yang#, Chunyan Gu#. PNPO-mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/β-catenin Pathway. Advanced Science, 2024, e2407681.（医学一区，IF: 14.3）
(4)Xiaozhu Tang; Zhendong Deng; Pinggang Ding; Wanting Qiang; Yue Lu; Shengyao Gao; Ye Hu; Ye Yang#; Juan Du#; Chunyan Gu#. A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing, Journal of Experimental & Clinical Cancer Research, 2022, 41(1):85.（医学一区，IF：12.658）
(5)Xiaozhu Tang, Mengjie Guo, Yuanjiao Zhang, Junxian Lv, Chunyan Gu#, Ye Yang#. Examining the evidence for mutual modulation between m6A modification and circular RNAs: current knowledge and future prospects. Journal of experimental & clinical cancer research. 2024;43(1):216. （医学一区，IF: 11.4）
(6)Jie Min, Jialei Mao, Hui Shi, Yumeng Peng, Xiaoning Xu, Mengjie Guo, Xiaozhu Tang, Ye Yang#, Chunyan Gu#. CUL4A-DDB1-circRFWD2 E3 ligase complex mediates the ubiquitination of p27 to promote multiple myeloma proliferation. Experimental Hematology & Oncology. 2024, 13(1):116. （医学一区，IF: 9.4）
(7)Chao Tang; Mengying Ke; Xichao Yu; Shanliang Sun; Xian Luo; Xin Liu; Yanyan Zhou; Ze Wang; Xing Cui#; Chunyan Gu#; Ye Yang#. GART Functions as a Novel Methyltransferase in the RUVBL1/β-Catenin Signaling Pathway to Promote Tumor Stemness in Colorectal Cancer. Advanced Science, 2023, 10(25): e2301264. （生物化学一区，IF：15.1）
(8)Chunyan Gu; Xichao Yu; Xiaozhu Tang; Leilei Gong; Jingquan Tan; Yuanjiao Zhang; Huili Zheng; Ze Wang; Chenqian Zhang; Yejin Zhu; Zuojian Zhou; Heming Yu; Kai Xu; Jinao Duan#; Xiaosong Gu#; Ye Yang#. Lycium barbarum L.-Derived miR162a Functions on Osteoporosis Through Directly Promoting Osteoblast Formation, Engineering, 2023. （工程技术一区，IF: 12.8）
(9)Rongfang Wei; Yan Zhu; Yuanjiao Zhang; Wene Zhao; Xichao Yu; Ling Wang; Chunyan Gu#; Xiaosong Gu#; Ye Yang#.AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation, Cancer communications, 2022.8.30.（医学一区，IF：15.283）
(10)Rongfang Wei; Xing Cui; Jie Min; Zigen Lin; Yanyan Zhou; Mengjie Guo; Xiaojuan An; Hao Liu; Siegfried Janz; Chunyan Gu#; Hongbo Wang#; Ye Yang#. NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma, Acta Pharmaceutica Sinica B, 2022;12(8):3313-3325. （医学一区，IF：14.903）
(11)Hongbo Wang; Qinghai Meng; Jinjun Qian; Muxi Li; Chunyan Gu#; Ye Yang#. Review: RNA-based diagnostic markers discovery and therapeutic targets development in cancer, Pharmacology & therapeutics, 2022, 234:108123. （医学一区，IF：13.4）
(12)Chunyan Gu; Yajun Wang; Lulin Zhang; Li Qiao; Shanliang Sun; Miaomiao Shao; Xiaozhu Tang; Pinggang Ding; Chao Tang; Yuhao Cao; Yanyan Zhou; Mengjie Guo; Rongfang Wei; Nianguang Li#; Yibei Xiao#; Jinao Duan#; Ye Yang#. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma, Journal of experimental & clinical cancer research, 2022, 41(1):11. （医学一区，IF：12.658）
(13)Zhen Hua; Rongfang Wei; Mengjie Guo; Zigen Lin; Xichao Yu; Xinying Li; Chunyan Gu#; Ye Yang#. YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis, Oncogene, 2022, 41(10):1482-1491. （医学一区，IF：8.756）
(14)Rui Li; Mengying Ke; Mingming Qi; Zhenru Han; Yuhao Cao; Zhendong Deng; Jinjun Qian#;Ye Yang#; Chunyan Gu#. G6PD promotes cell proliferation and dexamethasone resistance in multiple myeloma via increasing anti‑oxidant production and activating Wnt/β‑catenin pathway, Experimental Hematology & Oncology, 2022, 11(1):77. (医学一区，IF：8.593)
(15)Yuanjiao Zhang; Xichao Yu; Rongze Sun; Jie Min; Xiaozhu Tang; Zigen Lin; Siyuan Xie; Xinying Li; Shengfeng Lu; Zhidan Tian; Chunyan Gu#; Lesheng Teng#; Ye Yang#. Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication, Clinical and Translational Medicine, 2022;12(2):e684.（医学一区，IF：8.554）
(16)Ying Chen; Jinjun Qian; Pinggang Ding; Wang Wang; Xinying Li; Xiaozhu Tang; Chao Tang; Ye Yang#; Chunyan Gu#. Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation. Cell Death & Disease, 2022;13(9):822. （医学二区，IF：9.685）
(17)Chunyan Gu; Wang Wang; Xiaozhu Tang; Tingting Xu; Yanxin Zhang; Mengjie Guo; Rongfang Wei; Yajun Wang; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Fenghuang Zhan; Anja Seckinger; Dirk Hose; Jingxuan Pan#; Ye Yang#. CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma, Molecular Cancer, 2021, 20:84. （医学一区，IF：41.444）
(18)Xiaozhu Tang; Mengjie Guo; Pinggang Ding; Zhendong Deng; Mengying Ke; Yuxia Yuan; Yanyan Zhou; Zigen Lin; Muxi Li; Chunyan Gu#; Xiaosong Gu#; Ye Yang#. BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability, Signal Transduction and Targeted Therapy, 2021, 6:361. （医学一区，IF：38.104）
(19)Yuanjiao Zhang; Jinjun Qian; Chunyan Gu#; Ye Yang#. Alternative splicing and cancer: a systematic review, Signal Transduction and Targeted Therapy, 2021, 6:78. （医学一区，IF：38.104）
(20)Mengying Ke; Liqing Kang; Ling Wang; Shu Yang; Yajun Wang; Haiyan Liu; Chunyan Gu#; Hongming Huang#; Ye Yang#. CAR-T therapy alters synthesis of platelet‑activating factor in multiple myeloma patients, Journal of Hematology & Oncology, 2021, 14:90. （医学一区，IF：23.168）
(21)Fengjie Jiang; Xiaozhu Tang; Chao Tang; Zhen Hua; Mengying Ke; Chen Wang; Jiamin Zhao; Shengyao Gao; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Fenghuang Zhan; Chunyan Gu#; Ye Yang#. HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A‑dependent stabilization of ILF3 mRNA, Journal of Hematology & Oncology, 2021, 14:54. （医学一区，IF：23.168）
(22)Chunyan Gu; Ting Lu; Wang Wang; Miaomiao Shao; Rongfang Wei; Mengjie Guo; Rui Li; Li Qiao; Ye Hu; Fenghuang Zhan; Anja Seckinger; Dirk Hose; Ye Yang#. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma, Leukemia, 2021, 35(6):1803-1807. （医学一区，IF：12.883）
(23)Renjie Dou; Jinjun Qian; Wei Wu; Yanxin Zhang; Yuxia Yuan; Mengjie Guo; Rongfang Wei; Shu Yang; Artur Jurczyszyn; Siegfried Janz; Meral Beksac; Chunyan Gu#; Ye Yang#. Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma, Cell Death & Disease, 2021, 12:206. （医学二区，IF：9.685）
